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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr27671

Uniprot ID

N2DL2_HUMAN

Uniprot Acc

Q9BZM5;Q5VUN4;

Protein name

NKG2D ligand 2

Comment

FUNCTION:Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface.||SUBUNIT:Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.||SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor, GPI-anchor. Secreted.||TISSUE SPECIFICITY:Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.||MISCELLANEOUS:The ULBPs are u

Subcellular localization

Cell membrane;Lipid-anchor, GPI-anchor.Secreted.

Gene name

UL16 binding protein 2

Protein sequence

MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVI PKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGK KLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEP LTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRM WTTVHPGARKMKEKWENDKVVAMSFHYFSMGDCIGWLED FLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLL IILPCFILPGI

Database cross reference

RefSeq Protein accession:NP_079493
RefSeq Protein gi:13376824

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0031225;C:anchored to membrane;IEA:UniProtKB-KW. GO:0009986;C:cell surface;IDA:BHF-UCL. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0042612;C:MHC class I protein complex;IEA:InterPro.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB.

GO-P

GO:0019882;P:antigen processing and presentation;IEA:InterPro. GO:0006955;P:immune response;IEA:InterPro. GO:0030101;P:natural killer cell activation;NAS:UniProtKB. GO:0050776;P:regulation of immune response;TAS:Reactome.