HuLPr27672

Uniprot ID

N2DL3_HUMAN

Uniprot Acc

Q9BZM4;Q8IZX5;Q8TE75;

Protein name

NKG2D ligand 3

Comment

FUNCTION:Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.||SUBUNIT:Does not interact with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.||SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor, GPI-anchor.||MISCELLANEOUS:The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.||MISCELLANEOUS:The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which are pseudogenes.||SIMILARITY:Belongs to

Subcellular localization

Cell membrane;Lipid-anchor, GPI-anchor.

Gene name

UL16 binding protein 3

Protein sequence

MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTI IHLPRHGQQWCEVQSQVDQKNFLSYDCGSDKVLSMGHLE EQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSG PLTLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNR KWTVVHAGARRMKEKWEKDSGLTTFFKMVSMRDCKSWLR DFLMHRKKRLEPTAPPTMAPGLAQPKAIATTLSPWSFLI ILCFILPGI

Database cross reference

RefSeq Protein accession:NP_078794
RefSeq Protein gi:13375656

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0031225;C:anchored to membrane;IEA:UniProtKB-KW. GO:0042612;C:MHC class I protein complex;IEA:InterPro.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB.

GO-P

GO:0019882;P:antigen processing and presentation;IEA:InterPro. GO:0006955;P:immune response;IEA:InterPro. GO:0030101;P:natural killer cell activation;NAS:UniProtKB.