Protein basic information
| LiverAtlas Protein ID |
HuLPr27683 |
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Uniprot ID |
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Uniprot Acc |
Q9BXJ9;D3DNY6;Q52LG9;Q8IWH4;Q8NEV2;Q9H8P6; |
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Protein name |
N-alpha-acetyltransferase 15, NatA auxiliary subunit |
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Comment |
FUNCTION:The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.||SUBUNIT:Interacts with NAA10, XRCC6, NAA50 and XRCC5.||INTERACTION:Q9BSU3:NAA11; NbExp=1; IntAct=EBI-1042540, EBI-2585120;||SUBCELLULAR LOCATION:Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q9BXJ9-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9BXJ9-4; Sequence=VSP 012560, VSP 012561;||TISSUE SPECIFICITY:Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callos |
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Subcellular localization |
Cytoplasm.Nucleus. |
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Gene name |
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Protein sequence
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MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNP KFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKS HVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILR DLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIA YHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQ NQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLL QLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANML ERLKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKF LRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETS LKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPS IALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARW MDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFT REGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKC HEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDV LRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTAN MSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQK KKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPL KNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDS SHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNRLF GATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQK RAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEA AEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSSAEAEELANEI |
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Database cross reference |
RefSeq Protein accession:NP_476516
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver;Human Liver Organelles;Chinese Liver;French Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005667;C:transcription factor complex;IDA:UniProtKB. |
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GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. |
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GO-P |
GO:0001525;P:angiogenesis;IEA:UniProtKB-KW. GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0006474;P:N-terminal protein amino acid acetylation;IDA:UniProtKB. GO:0045893;P:positive regulation of transcription, DNA-dependent;IDA:UniProtKB. GO:000 |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr27683 |
PHOSPHORYLATION |
855 |
S |
Phospho-ELM |
HTP |
N |
 
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|
|
HuLPr27683 |
PHOSPHORYLATION |
856 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr27683 |
PHOSPHORYLATION |
302 |
S |
PhosphoSitePlus |
LTP |
N |
|
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HuLPr27683 |
ACETYLATION |
756 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr27683 |
ACETYLATION |
735 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr27683 |
ACETYLATION |
34 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27683 |
ACETYLATION |
262 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27683 |
PHOSPHORYLATION |
855 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27683 |
PHOSPHORYLATION |
856 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27683 |
PHOSPHORYLATION |
280 |
Y |
PhosphoSitePlus |
LTP |
N |
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