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Protein basic information

LiverAtlas Protein ID

HuLPr27700

Uniprot ID

NACAD_HUMAN

Uniprot Acc

O15069;

Protein name

NAC-alpha domain-containing protein 1

Comment

FUNCTION:May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Nucleus (By similarity).||SIMILARITY:Belongs to the NAC-alpha family.||SIMILARITY:Contains 1 NAC-A/B (NAC-alpha/beta) domain.

Subcellular localization

Cytoplasm(By similarity).Nucleus(By similarity).

Gene name

NAC alpha domain containing

Protein sequence

MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRR EPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGA PSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPR IVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCS QGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGD ARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCS LSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPP SSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPF QGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEG EEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDS DSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGG AKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVT EEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGE EETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLP TPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIV PRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATI VSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAAT LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA TLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA AATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKP VAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK PVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGP EPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPR PAPEEKNAALPTVPEPAALDQVQQ

Database cross reference

RefSeq Protein accession:NP_001139806
RefSeq Protein gi:226437579

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-P

GO:0015031;P:protein transport;IEA:UniProtKB-KW.