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Protein basic information

LiverAtlas Protein ID

HuLPr27713

Uniprot ID

NAGPA_HUMAN

Uniprot Acc

Q9UK23;B2RAS1;Q96EJ8;

Protein name

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Comment

FUNCTION:Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step.||CATALYTIC ACTIVITY:Glycoprotein N-acetyl-D-glucosaminyl-phospho- D-mannose + H(2)O = N-acetyl-D-glucosamine + glycoprotein phospho- D-mannose.||PATHWAY:Protein modification; protein glycosylation.||SUBUNIT:Homotetramer arranged as two disulfide-linked homodimers (By similarity).||SUBCELLULAR LOCATION:Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Note=Cis/medial Golgi.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UK23-1; Sequence=Displayed; Name=2; IsoId=Q9UK23-2; Sequence=VSP 012269; Name=3; IsoId=Q9UK23-3; Sequence=VSP 012267, VSP 012268;||TISSUE SPECIFICITY:Isoform 2 may be brain-specific.||DOMAIN:The tyrosine-based internalization signal may be essential for its retrieval from

Subcellular localization

Golgi apparatus, Golgi stack membrane;Single-pass type I membrane protein.

Gene name

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Protein sequence

MATSTGRWLLLRLALFGFLWEASGGLDSGASRDDDLLLPY PRARARLPRDCTRVRAGNREHESWPPPPATPGAGGLAVR TFVSHFRDRAVAGHLTRAVEPLRTFSVLEPGGPGGCAAR RRATVEETARAADCRVAQNGGFFRMNSGECLGNVVSDER RVSSSGGLQNAQFGIRRDGTLVTGYLSEEEVLDTENPFV QLLSGVVWLIRNGSIYINESQATECDETQETGSFSKFVN VISARTAIGHDRKGQLVLFHADGQTEQRGINLWEMAEFL LKQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWR CPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGHFW RGPGCDELDCGPSNCSQHGLCTETGCRCDAGWTGSNCSE ECPLGWHGPGCQRPCKCEHHCPCDPKTGNCSVSRVKQCL QPPEATLRAGELSFFTRTAWLALTLALAFLLLISTAANL SLLLSRAERNRRLHGDYAYHPLQEMNGEPLAAEKEQPGGAHNPFKD

Database cross reference

RefSeq Protein accession:NP_057340
RefSeq Protein gi:66346700

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0032580;C:Golgi cisterna membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;TAS:ProtInc.

GO-F

GO:0003944;F:N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity;TAS:ProtInc.

GO-P

GO:0005975;P:carbohydrate metabolic process;TAS:ProtInc. GO:0007040;P:lysosome organization;TAS:ProtInc. GO:0006464;P:protein modification process;TAS:ProtInc. GO:0006622;P:protein targeting to lysosome;TAS:ProtInc.