HuLPr27727

Uniprot ID

NALP3_HUMAN

Uniprot Acc

Q96P20;B7ZKT2;B7ZKT3;O75434;Q17RS2;Q59H68;Q5JQS8;Q5JQS9;Q6TG35;Q8TCW0;Q8TEU9;Q8WXH9;

Protein name

NACHT, LRR and PYD domains-containing protein 3

Comment

FUNCTION:May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.||SUBUNIT:Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase- 5, leading to processing of IL1B and IL18.||SUBCELLULAR LOCATION:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=2; IsoId=Q96P20-1; Sequence=Displayed; Name=1; IsoId=Q96P20-2; Sequence=VSP 005520, VSP 005521; Name=3; IsoId=Q96P20-3; Sequence=VSP 005519; Name=4; IsoId=Q96P20-4; Sequence=VSP 005520; Name=5; IsoId=Q96P20-5; Sequence=VSP 005521; Note=No experimental confirmatio

Subcellular localization

Cytoplasm.

Gene name

NLR family, pyrin domain containing 3

Protein sequence

MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIP LPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAIN RRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWM GLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNAR LGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTC ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTIL ARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGD LIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDE HIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQ ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGK SLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGL CSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLF QKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVP GSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQ ERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQP SQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHM VSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDM VQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQS LTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCG LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL GNNDLGDLGVMMFCEVLKQQSCLL

Database cross reference

RefSeq Protein accession:NP_001073289
RefSeq Protein gi:119395764

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005737;C:cytoplasm;IDA:BHF-UCL.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0042834;F:peptidoglycan binding;TAS:HGNC. GO:0005515;F:protein binding;IPI:BHF-UCL.

GO-P

GO:0009595;P:detection of biotic stimulus;TAS:HGNC. GO:0006917;P:induction of apoptosis;NAS:UniProtKB. GO:0006954;P:inflammatory response;IMP:UniProtKB. GO:0042347;P:negative regulation of NF-kappaB import into nucleus;IDA:HGNC. GO:0032088;P:negative r

TCR