HuLPr27941

Uniprot ID

NETO2_HUMAN

Uniprot Acc

Q8NC67;Q7Z381;Q8ND51;Q96SP4;Q9NVY8;

Protein name

Neuropilin and tolloid-like protein 2

Comment

FUNCTION:Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).||SUBUNIT:Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NC67-1; Sequence=Displayed; Name=2; IsoId=Q8NC67-2; Sequence=VSP 012856, VSP 012857;||PTM:N-glycosylated (By similarity).||SIMILARITY:Contains 2 CUB domains.||SIMILARITY:Contains 1 LDL-receptor cl

Subcellular localization

Membrane;Single-pass type I membrane protein(Potential).

Gene name

neuropilin (NRP) and tolloid (TLL)-like 2

Protein sequence

MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHI PATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAA PRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLI DRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYS FIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQE EKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECK RNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRM WADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNS LVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGTIIG ITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQE VFDPPHYELFSLRDKEISADLADLSEELDNYQKMRRSST ASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQ PMKTFNSTFKKSSYTFKQGHECPEQALEDRVMEEIPCEI YVRGREDSAQASISIDF

Database cross reference

RefSeq Protein accession:NP_001188406
RefSeq Protein gi:319996652

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr27941

PHOSPHORYLATION

422

Y

PhosphoSitePlus

465407

LTP

HTP

N