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Protein basic information

LiverAtlas Protein ID

HuLPr27947

Uniprot ID

NEUA_HUMAN

Uniprot Acc

Q8NFW8;Q96AX5;Q9NQZ0;

Protein name

N-acylneuraminate cytidylyltransferase

Comment

FUNCTION:Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).||CATALYTIC ACTIVITY:CTP + N-acylneuraminate = diphosphate + CMP-N- acylneuraminate.||PATHWAY:Amino-sugar metabolism; N-acetylneuraminate metabolism.||SUBUNIT:Homotetramer; the active enzyme is formed by a dimer of dimers.||SUBCELLULAR LOCATION:Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NFW8-1; Sequence=Displayed; Name=2; IsoId=Q8NFW8-2; Sequence=VSP 012764; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Ubiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen.||DOMAIN:The BC2 (bas

Subcellular localization

Nucleus.

Gene name

cytidine monophosphate N-acetylneuraminic acid synthetase

Protein sequence

MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVE KPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAA LDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKD SSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKV AEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNL NPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKM AYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKE IKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISL LKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLA VVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPA DACSTAQKAVGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK

Database cross reference

RefSeq Protein accession:NP_061156
RefSeq Protein gi:8923900

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0008781;F:N-acylneuraminate cytidylyltransferase activity;IEA:EC.

GO-P

GO:0009103;P:lipopolysaccharide biosynthetic process;IEA:InterPro.

Pathway

Pathway name

Amino_Sugar_Metabolism