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Protein basic information

LiverAtlas Protein ID

HuLPr27996

Uniprot ID

NGBR_HUMAN

Uniprot Acc

Q96E22;B2RWQ4;O00251;

Protein name

Nogo-B receptor

Comment

FUNCTION:Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Able to regulate vascular remodeling and angiogenesis. Its similarity with UPP synthase proteins suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential). Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.||MISCELLANEOUS:Although strongly related to UPP synthase family proteins, it has no lipid transferase activity.||SIMILARITY:Belongs to the UPP synthase family.||SEQUENCE CAUTION:Sequence=AAB72234.1; Type=Frameshift; Positions=Several;

Subcellular localization

Membrane;Single-pass type I membrane protein(Potential).

Gene name

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)

Protein sequence

MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRC CRAASAAVLAPLGFTLRKPPAVGRNRRHHRHPRGGSCLA AAHHRMRWRADGRSLEKLPVHMGLVITEVEQEPSFSDIA SLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQ ELLGLDCSKYSPEFANSNDKDDQVLNCHLAVKVLSPEDG KADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGC PDPDLVLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISY EDFFSALRQYAACEQRLGK

Database cross reference

RefSeq Protein accession:NP_612468
RefSeq Protein gi:20270243

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW. GO:0016765;F:transferase activity, transferring alkyl or aryl (other than methyl) groups;IEA:InterPro.

GO-P

GO:0001525;P:angiogenesis;IEA:UniProtKB-KW. GO:0030154;P:cell differentiation;IEA:UniProtKB-KW.