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Protein basic information

LiverAtlas Protein ID

HuLPr28053

Uniprot ID

NKD2_HUMAN

Uniprot Acc

Q969F2;Q96EK8;Q9BSN0;

Protein name

Protein naked cuticle homolog 2

Comment

FUNCTION:Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.||SUBUNIT:Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with RNF25 and TGFA (via cytoplasmic domain).||INTERACTION:P01135:TGFA; NbExp=2; IntAct=EBI-1538629, EBI-1034374;||SUBCELLULAR LOCATION:Cell membrane. Cytoplasm. Cytoplasmic vesicle.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q969F2-1; Sequence=Displayed; Name=2; IsoId=Q969F2-2; Sequence=VSP 027900, VSP 027901;||TISSUE SPECIFICITY:Expressed in kidney, lung, pancreas and spleen.||DEVELOPMENTAL STAGE:Expressed in fetal kidney and lung.||DOMAIN:The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.||PTM:Ubiquitinated, leading to rapid proteasomal de

Subcellular localization

Cell membrane.Cytoplasm.Cytoplasmic vesicle.

Gene name

naked cuticle homolog 2 (Drosophila)

Protein sequence

MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAE RRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGRE HPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSV EEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDA SVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPT RCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPY CVDENTERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQ GRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASEPA ARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKA FSYYLPAVLPPQAPQDGHHLPQPPPPPYGHKRYRQKGRE GHSPLKAPHAQPATVEHEVVRDLPPTPAGEGYAVPVIQR HEHHHHHEHHHHHHHHHFHPS

Database cross reference

RefSeq Protein accession:NP_149111
RefSeq Protein gi:14916427

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016023;C:cytoplasmic membrane-bounded vesicle;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0031625;F:ubiquitin protein ligase binding;IPI:UniProtKB.

GO-P

GO:0006887;P:exocytosis;IEA:UniProtKB-KW. GO:0016055;P:Wnt receptor signaling pathway;IEA:UniProtKB-KW.

Pathway

Pathway name

Canonical_Wnt_signaling_pathway