HuLPr28090

Uniprot ID

NMD3A_HUMAN

Uniprot Acc

Q8TCU5;B3DLF9;Q5VTR3;Q8TF29;Q8WXI6;

Protein name

Glutamate [NMDA] receptor subunit 3A

Comment

FUNCTION:NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).||SUBUNIT:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in post-synaptic plasma membran

Subcellular localization

Cell membrane;Multi-pass membrane protein(By similarity).Cell junction, synapse, postsynaptic cell membrane(By similarity).Cell junction, synapse, postsynaptic cell membrane, postsynaptic density(By similarity).

Gene name

glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

Protein sequence

MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQI LKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRD EPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGAR AEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAG LGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSAL LAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNP LHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDW NITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQI QLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPEL RWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQD AMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSG QYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQ HDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQ HPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM TNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEK IAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTA HMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAA PIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGL TPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTG RFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIH DPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRY NVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADC KLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHG FMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVL LCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTS QRLHRAINTSFIEEKQQHFKTKRV

Database cross reference

RefSeq Protein accession:NP_597702
RefSeq Protein gi:223278356

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0017146;C:N-methyl-D-aspartate selective glutamate receptor complex;IDA:UniProtKB. GO:0043005;C:neuron projection;IDA:UniProtKB. GO:0043025;C:neuronal cell body;IDA:UniProtKB. GO:0030288;C:outer membrane-

GO-F

GO:0005234;F:extracellular-glutamate-gated ion channel activity;IEA:InterPro. GO:0016594;F:glycine binding;IDA:UniProtKB. GO:0042802;F:identical protein binding;IPI:UniProtKB. GO:0004972;F:N-methyl-D-aspartate selective glutamate receptor activity;IDA:U

GO-P

GO:0045471;P:response to ethanol;IDA:UniProtKB.

Methadone_Pathway