Protein basic information
| LiverAtlas Protein ID |
HuLPr28161 |
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Uniprot ID |
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Uniprot Acc |
Q9NPH5;A8K715;Q5K3R4;Q5K3R5;Q5K3R6;Q5K3R8;Q7Z7G3;Q86V92; |
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Protein name |
NADPH oxidase 4 |
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Comment |
FUNCTION:Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.||ENZYME REGULATION:Inhibited by plumbagin (By similarity). Activated by phorbol 12-myristate 13-acetate (PMA). Activated by insulin. Inhibited by diphenylene iodonium.||SUBUNIT:Interacts with protein disulfide isomerase (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4.||SUBCELLULAR LOCATION:End |
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Subcellular localization |
Endoplasmic reticulum membrane;Multi-pass membrane protein.Cell membrane;Multi-pass membrane protein(Probable).Cell junction, focal adhesion(Probable).Nucleus(Probable). |
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Gene name |
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Protein sequence
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MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQG PEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTL LAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGV HVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFT TVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNL FFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQ NISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEP RFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIIS VMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENH PFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQ DSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVA GGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSF RWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKII GEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCC GPNSLSKTLHKLSNQNNSYGTRFEYNKESFS |
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Database cross reference |
RefSeq Protein accession:NP_001137308
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0005925;C:focal adhesion;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;TAS:UniProtKB. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0009055;F:electron carrier activity;TAS:UniProtKB. GO:0050660;F:flavin adenine dinucleotide binding;TAS:UniProtKB. GO:0020037;F:heme binding;TAS:UniProtKB. GO:0016174;F:NAD(P)H oxidase activity;TAS:UniProtKB. GO:0000166;F:nucleotide binding;TAS:UniP |
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GO-P |
GO:0007569;P:cell aging;ISS:UniProtKB. GO:0000902;P:cell morphogenesis;ISS:UniProtKB. GO:0006954;P:inflammatory response;TAS:UniProtKB. GO:0008285;P:negative regulation of cell proliferation;ISS:UniProtKB. GO:0055114;P:oxidation-reduction process;IDA:U |
Pathway
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