Protein basic information
| LiverAtlas Protein ID |
HuLPr28163 |
|
Uniprot ID |
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Uniprot Acc |
Q86UR1;O60533;Q29VU9;Q29VV0;Q2TAM1;Q8IUS3; |
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Protein name |
NADPH oxidase activator 1 |
|
Comment |
FUNCTION:Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.||SUBUNIT:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct.||SUBCELLULAR LOCATION:Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86UR1-1; Sequence=Displayed; Name=2; IsoId=Q86UR1-2; Sequence=VSP 030336; Note=Mostly inactive for NOX1 activation. Doe |
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Subcellular localization |
Cytoplasm.Cell membrane. |
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Gene name |
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Protein sequence
|
MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARL CFNAGCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRG VANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFK LQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSL NGLDSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEP VDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSL IMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQ VGKQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPL VTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLG QLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQ CRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLC EVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQGDQP |
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Database cross reference |
RefSeq Protein accession:NP_006638
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0043020;C:NADPH oxidase complex;IDA:BHF-UCL. |
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GO-F |
GO:0048365;F:Rac GTPase binding;IPI:BHF-UCL. GO:0016176;F:superoxide-generating NADPH oxidase activator activity;IMP:BHF-UCL. |
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GO-P |
GO:0010310;P:regulation of hydrogen peroxide metabolic process;IMP:BHF-UCL. GO:0060263;P:regulation of respiratory burst;IMP:BHF-UCL. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr28163 |
PHOSPHORYLATION |
110 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr28163 |
PHOSPHORYLATION |
172 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr28163 |
PHOSPHORYLATION |
468 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr28163 |
PHOSPHORYLATION |
282 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr28163 |
PHOSPHORYLATION |
239 |
S |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
