HuLPr28165

Uniprot ID

NOXO1_HUMAN

Uniprot Acc

Q8NFA2;Q86YM1;Q8NFA3;Q96B73;

Protein name

NADPH oxidase organizer 1

Comment

FUNCTION:Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.||SUBUNIT:Interacts with NOX1, NOXA1, CYBA/p22phox and NCF2/p67phox. Interacts with SH3PXD2A and SH3PXD2B.||SUBCELLULAR LOCATION:Isoform 3:Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=NOXO1gamma; IsoId=Q8NFA2-1; Sequence=Displayed; Name=2; Synonyms=NOXO1delta; IsoId=Q8NFA2-2; Sequence=VSP 017560; Name=3; Synonyms=NOXO1beta; IsoId=Q8NFA2-3; Sequence=VSP 017561; Name=4; S

Subcellular localization

Isoform 3:Cell membrane;Peripheral membrane protein;Cytoplasmic side.

Gene name

NADPH oxidase organizer 1

Protein sequence

MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRR SWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASL DAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSP TITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGR LSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLL RHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSL GSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGW WLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAG EARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRAL ERRPRRQGRPRGCVDSVPHPTTEQ

Database cross reference

RefSeq Protein accession:NP_653204
RefSeq Protein gi:21389405

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Human Liver Organelles;

GO:0043020;C:NADPH oxidase complex;IDA:BHF-UCL.

GO-F

GO:0019899;F:enzyme binding;IPI:BHF-UCL. GO:0035091;F:phosphatidylinositol binding;IEA:InterPro. GO:0016176;F:superoxide-generating NADPH oxidase activator activity;TAS:BHF-UCL.

GO-P

GO:0007154;P:cell communication;IEA:InterPro. GO:0010310;P:regulation of hydrogen peroxide metabolic process;TAS:BHF-UCL. GO:0060263;P:regulation of respiratory burst;TAS:BHF-UCL.

RAC1_signaling_pathway