HuLPr28198

Uniprot ID

NPL_HUMAN

Uniprot Acc

Q9BXD5;B2R839;Q4G0Q8;Q4G0Z2;Q64L88;Q6PEL0;

Protein name

N-acetylneuraminate lyase

Comment

FUNCTION:Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface (By similarity).||CATALYTIC ACTIVITY:N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.||PATHWAY:Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate:step 1/5.||SUBUNIT:Homotetramer (By similarity).||SUBCELLULAR LOCATION:Cytoplasm (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BXD5-1; Sequence=Displayed; Name=2; IsoId=Q9BXD5-2; Sequence=VSP 022518; Name=3; IsoId=Q9BXD5-3; Sequence=VSP 022522; Note=No experimental confirmation available; Name=4; IsoId=Q9BXD5-4; Sequence=VSP 022521, VSP 022522; Note=No experimental confirmation available; Name=5; IsoId=Q9BXD5-5; Sequence=VSP 022519, VSP 022520; Note=No experimental confirmation available. Ma

Subcellular localization

Cytoplasm(By similarity).

Gene name

N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)

Protein sequence

MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKE QGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLD QVIIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKP WTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEE LLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAF LFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFE QKDFSLALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVS GIPMGPPRLPLQKASREFTDSAEAKLKSLDFLSFTDLKD GNLEAGS

Database cross reference

RefSeq Protein accession:NP_001186979
RefSeq Protein gi:318037618

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0008747;F:N-acetylneuraminate lyase activity;IEA:EC.

GO-P

GO:0005975;P:carbohydrate metabolic process;IEA:UniProtKB-KW.

Amino_Sugar_Metabolism