HuLPr28217

Uniprot ID

NPTN_HUMAN

Uniprot Acc

Q9Y639;B7Z4D3;B7ZLL2;Q17R52;Q59EJ9;Q6NVX7;Q9Y640;

Protein name

Neuroplastin

Comment

FUNCTION:Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein (Potential). Note=Enriched at post-synaptic density (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=2; Synonyms=SDR-1-beta; IsoId=Q9Y639-2; Sequence=Displayed; Name=1; Synonyms=SDR-1-alpha; IsoId=Q9Y639-1; Sequence=VSP 039251; Name=3; IsoId=Q9Y639-3; Sequence=VSP 039251, VSP 039253; Name=4; IsoId=Q9Y639-4; Sequence=VSP 039252; Note=No experimental confirmation available; Name=5; IsoId=Q9Y639-5; Sequence=VSP 039253;||TISSUE SPECIFICITY:Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).||DOMAIN:Some isofo

Subcellular localization

Cell membrane;Single-pass type I membrane protein(Potential).

Gene name

neuroplastin

Protein sequence

MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSE TKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLW DGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRA SNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVI IRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRK NASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVK AAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKK ENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGE YECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIII LVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN

Database cross reference

RefSeq Protein accession:NP_001154835
RefSeq Protein gi:238624147

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. GO:0042734;C:presynaptic membrane;ISS:HGNC.

GO-F

GO:0050839;F:cell adhesion molecule binding;ISS:HGNC. GO:0005105;F:type 1 fibroblast growth factor receptor binding;ISS:UniProtKB.

GO-P

GO:0007204;P:elevation of cytosolic calcium ion concentration;ISS:UniProtKB. GO:0007156;P:homophilic cell adhesion;ISS:HGNC. GO:0060291;P:long-term synaptic potentiation;ISS:UniProtKB. GO:0045743;P:positive regulation of fibroblast growth factor recepto