HuLPr28251

Uniprot ID

NRAP_HUMAN

Uniprot Acc

Q86VF7;O15500;Q5VWI3;Q5VWI4;Q6MZK3;Q6N026;Q6N059;Q6NSH8;Q6PDB0;Q719H6;Q86TC5;Q86TD6;Q86TE6;Q86VF6;Q8N3R6;Q8N8F9;Q8TCH0;Q96MG4;

Protein name

Nebulin-related-anchoring protein

Comment

FUNCTION:May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix (By similarity).||SUBUNIT:Interacts with actin, alpha-actinin, KBTBD10, TLN1 and VCL (By similarity).||SUBCELLULAR LOCATION:Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86VF7-1; Sequence=Displayed; Name=2; IsoId=Q86VF7-2; Sequence=VSP 052166; Note=Gene prediction based on EST data; Name=3; IsoId=Q86VF7-3; Sequence=VSP 052165, VSP 052166; Note=Gene prediction based on EST data; Name=4; IsoId=Q86VF7-4; Sequence=VSP 052165;||TISSUE SPECIFICITY:Expressed in cardiac and skeletal muscle.||SIMILARITY:Contains 1 LIM zinc-binding domain.||SIMILARITY:Contains 44 nebulin repeats.||SEQUENCE CAUTION:Sequence=AAH58825.1; Type=Miscellaneous discrepancy; Note=Contaminati

Subcellular localization

Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.

Gene name

nebulin-related anchoring protein

Protein sequence

MNVQPCSRCGYGVYPAEKISCIDQIWHKACFHCEVCKMML SVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLNVRTF PEAISGIHDQEDGEQCKSVFHWDMKSKDKEGAPNRQPLA NERAYWTGYGEGNAWCPGALPDPEIVRMVEARKSLGEEY TEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRG HDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQ RGKGSFPAMITPAYQIAKRANELASDVRYHQQYQKEMRG MAGPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPA MITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPA QDNLVLKQAQSVNKLVSEVEYKKDLESSRGHSINYCETP QFRNVSKISKFTSDNKYKENYQNHMRGRYEGVGMDRRTL HAMKVGSLASNVAYKADYKHDIVDYNYPATLTPSYQTAM KLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLS HVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFSEVKY KEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEE YEKTKGKAMGTADSRLLHSLQIAKMSSEVEYKKGFEESK TRFHLPMDMVNIRHAKKAQTLASDLDYRKKLHEYTVLPE DMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNL EQAKKAGQLVSEKNYRQRVDELKFTSVTDSSQMEHAKKS QELQSGVAYKAGNEQSVHQYTISKDEPLFLQARANAANL SEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEV KYKEDYERSRGKLIGAKDVQGDSQMSHSLQMSKLQSELE YKKGFEDTKSQCHVSLDMVHLVHARKAQHLATDVGYKTA EHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMG WVATGSLNVEQAKKAGELISEKKYRQHPDALKFTSIKDT PEMVQARISYTQAVDRLYREQGEN

Database cross reference

RefSeq Protein accession:NP_006166
RefSeq Protein gi:46049092

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005916;C:fascia adherens;ISS:UniProtKB. GO:0005927;C:muscle tendon junction;ISS:UniProtKB.

GO-F

GO:0003779;F:actin binding;ISS:UniProtKB. GO:0051371;F:muscle alpha-actinin binding;ISS:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr28251

ACETYLATION

916

K

PhosphoSitePlus

14367049

LTP

N

HuLPr28251

PHOSPHORYLATION

523

Y

PhosphoSitePlus

977680

HTP

N

HuLPr28251

PHOSPHORYLATION

53

Y

PhosphoSitePlus

1037815

LTP

HTP

N

HuLPr28251

PHOSPHORYLATION

68

Y

PhosphoSitePlus

1037819

LTP

N