HuLPr28256

Uniprot ID

NRCAM_HUMAN

Uniprot Acc

Q92823;A4D0S3;O15051;O15179;Q9UHI3;Q9UHI4;

Protein name

Neuronal cell adhesion molecule

Comment

FUNCTION:Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity).||SUBUNIT:Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q92823-1; Sequence=Displayed; Name=2; IsoId=Q92823-2; Sequence=VSP 007841, VSP 007842; Name=3; IsoId=Q92823-3; Sequence=VSP 007838, VSP 007840; Note=No experimental confirmation available; Name=4; IsoId=Q92823-4; Sequence=VSP 007837, VSP 007839, VSP 007840; Note=No experimental confirmation available; Name=5; IsoId=Q92823-5; Sequence=VSP 007843;||TISSUE SPECIFICITY:Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, s

Subcellular localization

Cell membrane;Single-pass type I membrane protein(Potential).

Gene name

neuronal cell adhesion molecule

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLE DLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYE GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL QSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQ GLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPIS VKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPE GNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPK NRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHT ISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPR ISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVY QCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN RPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTW IVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNR ELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSV SASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQ LSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGT QTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTK ASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQ YKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIK VQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNS TLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRH IEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEG PASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPS HPNGILTEYTLKYQPINSTHELGP

Database cross reference

RefSeq Protein accession:NP_001032209
RefSeq Protein gi:81158226

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0009897;C:external side of plasma membrane;NAS:UniProtKB. GO:0005887;C:integral to plasma membrane;NAS:UniProtKB.

GO-F

GO:0030506;F:ankyrin binding;IDA:UniProtKB.

GO-P

GO:0001525;P:angiogenesis;IEP:UniProtKB. GO:0007411;P:axon guidance;TAS:Reactome. GO:0007413;P:axonal fasciculation;NAS:UniProtKB. GO:0016337;P:cell-cell adhesion;NAS:UniProtKB. GO:0007417;P:central nervous system development;NAS Error!!!Go back to the login page