HuLPr28286

Uniprot ID

NSD3_HUMAN

Uniprot Acc

Q9BZ95;D3DSX1;Q1RMD3;Q3B796;Q6ZSA5;Q9BYU8;Q9BYU9;Q9H2M8;Q9H9W9;Q9NXA6;

Protein name

Histone-lysine N-methyltransferase NSD3

Comment

FUNCTION:Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.||CATALYTIC ACTIVITY:S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].||SUBCELLULAR LOCATION:Nucleus (By similarity). Chromosome (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BZ95-1; Sequence=Displayed; Name=2; IsoId=Q9BZ95-2; Sequence=VSP 021430; Name=3; IsoId=Q9BZ95-3; Sequence=VSP 021428, VSP 021429; Name=4; IsoId=Q9BZ95-4; Sequence=VSP 021427; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.||DISEASE:Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed

Subcellular localization

Nucleus(By similarity).Chromosome(By similarity).

Gene name

Wolf-Hirschhorn syndrome candidate 1-like 1

Protein sequence

MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDI AEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISV YETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPN TRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKI TKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEK RKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVS EKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLV WSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFF SNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSE KQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYT FIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIA WKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFA LQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIIST PNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSE SEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISD SCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTV CQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFIC MECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRK FPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCL RCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSA VNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR AELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPEC LSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPA EICNPRSVPLNIQGLKHDLGDFPV

Database cross reference

RefSeq Protein accession:NP_060248
RefSeq Protein gi:13699813

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005694;C:chromosome;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IC:UniProtKB.

GO-F

GO:0018024;F:histone-lysine N-methyltransferase activity;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0030154;P:cell differentiation;NAS:UniProtKB. GO:0016049;P:cell growth;NAS:UniProtKB. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr28286

ACETYLATION

790

K

PhosphoSitePlus

466807

LTP

N