Protein basic information
| LiverAtlas Protein ID |
HuLPr28362 |
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Uniprot ID |
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Uniprot Acc |
Q9BQG2;B3KUW2;Q8TAL7; |
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Protein name |
Peroxisomal NADH pyrophosphatase NUDT12 |
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Comment |
FUNCTION:Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.||CATALYTIC ACTIVITY:NAD(+) + H(2)O = AMP + NMN.||COFACTOR:Magnesium or manganese (By similarity).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=11 uM for NADH; KM=16 uM for NADPH; KM=190 uM for NAD; pH dependence: Optimum pH is 8-9;||SUBCELLULAR LOCATION:Peroxisome.||SIMILARITY:Belongs to the Nudix hydrolase family. NudC subfamily.||SIMILARITY:Contains 3 ANK repeats.||SIMILARITY:Contains 1 nudix hydrolase domain. |
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Subcellular localization |
Peroxisome. |
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Gene name |
nudix (nucleoside diphosphate linked moiety X)-type motif 12 |
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Protein sequence
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MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLN ETSENGWTALMYAARNGHPEIVQFLLEKGCDRSIVNKSR QTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECE NYFSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLN PLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITL IFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPI AAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSV LAWHSRYKFCPTCGNATKIEEGGYKRLCLKEDCPSLNGV HNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTC LAGFIEPGETIEDAVRREVEEESGVKVGHVQYVACQPWP MPSSLMIGCLALAVSTEIKVDKNEIEDARWFTREQVLDV LTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL |
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Database cross reference |
RefSeq Protein accession:NP_113626
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IDA:LIFEdb. GO:0005777;C:peroxisome;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0000210;F:NAD+ diphosphatase activity;IEA:EC. |
Pathway
| Pathway name |
