HuLPr28366

Uniprot ID

NUD16_HUMAN

Uniprot Acc

Q96DE0;Q96N82;

Protein name

U8 snoRNA-decapping enzyme

Comment

FUNCTION:RNA-decapping enzyme that binds specifically to U8 snoRNA. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and m227G caps from U8 snoRNA. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species (in vitro).||COFACTOR:Magnesium, manganese or cobalt. Binds 3 or 4 divalent metal cations. Acts specifically on U8 snoRNA with magnesium as cofactor. Has broad substrate specificity with bound manganese or cobalt (in vitro).||SUBUNIT:Homodimer.||SUBCELLULAR LOCATION:Nucleus, nucleolus (By similarity). Nucleus, nucleoplasm (By similarity). Note=Predominantly localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity).||SIMILARITY:Belongs to the Nudix hydrolase family.||SIMILARITY:Contains 1 nudix hydrolase domain.||SEQUENCE CAUTION:Sequence=BAB71024.1; Type=Erroneous initiation; Note=Translation N-terminally

Subcellular localization

Nucleus, nucleolus(By similarity).Nucleus, nucleoplasm(By similarity).

Gene name

nudix (nucleoside diphosphate linked moiety X)-type motif 16

Protein sequence

MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIP LRYAILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELRE ELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLE ELLAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPT FLENSFIGSAREQLLEALQDLGLLQSGSISGLKIPAHH

Database cross reference

RefSeq Protein accession:NP_001165377
RefSeq Protein gi:285026441

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005730;C:nucleolus;IEA:UniProtKB-SubCell. GO:0005654;C:nucleoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0016787;F:hydrolase activity;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0003723;F:RNA binding;IEA:UniProtKB-KW.