HuLPr28751

Uniprot ID

O78759_HUMAN

Uniprot Acc

O78759;

Protein name

NADH-ubiquinone oxidoreductase chain 2

Comment

FUNCTION:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).||CATALYTIC ACTIVITY:NADH + ubiquinone = NAD(+) + ubiquinol.||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).||SIMILARITY:Belongs to the complex I subunit 2 family.

Subcellular localization

Mitochondrion inner membrane;Multi-pass membrane protein(By similarity).

Gene name

MTND2

Protein sequence

MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAF IPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNM LSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEV TQGTPLTSGLLLLTWQKLAPISIMYQISPSLDVSLLLTL SILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPY NPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWN KLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNN SLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKM KWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

Database cross reference

RefSeq Protein accession:YP_003024027
RefSeq Protein gi:251831108

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell. GO:0070469;C:respiratory chain;IEA:UniProtKB-KW.

GO-F

GO:0008137;F:NADH dehydrogenase (ubiquinone) activity;IEA:EC.

GO-P

GO:0006120;P:mitochondrial electron transport, NADH to ubiquinone;IEA:InterPro. GO:0006810;P:transport;IEA:UniProtKB-KW.