HuLPr28861

Uniprot ID

OGFD1_HUMAN

Uniprot Acc

Q8N543;Q9H7U5;Q9H9J9;Q9HA87;Q9HCG0;Q9NVB6;

Protein name

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

Comment

COFACTOR:Binds 1 Fe(2+) ion per subunit (By similarity).||COFACTOR:Ascorbate (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N543-1; Sequence=Displayed; Name=2; IsoId=Q8N543-2; Sequence=VSP 025852; Note=No experimental confirmation available;||SIMILARITY:Belongs to the TPA1 family.||SIMILARITY:Contains 1 Fe2OG dioxygenase domain.||SEQUENCE CAUTION:Sequence=BAB13438.1; Type=Erroneous initiation; Sequence=BAB14880.1; Type=Erroneous initiation;

Gene name

2-oxoglutarate and iron-dependent oxygenase domain containing 1

Protein sequence

MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVA EAWSRRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGL QKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKI LFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDD ELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQI VKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISG WFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTY LDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEH GHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEA LFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEG TSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKES SVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCE GWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRE TLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE

Database cross reference

RefSeq Protein accession:NP_060703
RefSeq Protein gi:94536836

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO-F

GO:0005506;F:iron ion binding;IEA:InterPro. GO:0031418;F:L-ascorbic acid binding;IEA:UniProtKB-KW. GO:0016706;F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorp

GO-P

GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.