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Protein basic information

LiverAtlas Protein ID

HuLPr29049

Uniprot ID

OSGI1_HUMAN

Uniprot Acc

Q9UJX0;Q52M33;Q86UQ1;Q96S88;Q9BZ70;

Protein name

Oxidative stress-induced growth inhibitor 1

Comment

FUNCTION:Regulates the differentiation and proliferation of normal cells through the regulation of cell death.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=2; Synonyms=2b; IsoId=Q9UJX0-1; Sequence=Displayed; Name=1; Synonyms=1a, 2a; IsoId=Q9UJX0-2; Sequence=VSP 010500; Name=3; Synonyms=2c; IsoId=Q9UJX0-3; Sequence=Not described;||TISSUE SPECIFICITY:Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.||INDUCTION:By pregnancy.||MISCELLANEOUS:Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.||SIMILARITY:Belongs to the OKL38 family.||SEQUENCE CAUTION:Sequence=AAF06662.1; Type=Frameshift; Positions=493, 523, 534, 554; Sequence=AAK01722.2; Type=Erroneous gene model prediction;

Gene name

oxidative stress induced growth inhibitor 1

Protein sequence

MGKWRPRGCCRGNMQCRQEVPATLTSSELFSTRNQPQPQP QPLLADAPVPWAVASRMCLTPGQGCGHQGQDEGPLPAPS PPPAMSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLL SGYTPYTKPDAIHPHPLLQRKLTEAPGVSILDQDLDYLS EGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRK EHAIPHVVLGRNLPGGAWHSIEGSMVILSQGQWMGLPDL EVKDWMQKKRRGLRNSRATAGDIAHYYRDYVVKKGLGHN FVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQ AQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHEL SALEAATRVGAVTPASDPVLIIGAGLSAADAVLYARHYN IPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQ SILSPSPYEGYRSLPRHQLLCFKEDCQAVFQDLEGVEKV FGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSAKRN PIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAV ASSLLRKETRKPP

Database cross reference

RefSeq Protein accession:NP_037502
RefSeq Protein gi:118572590

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-F

GO:0008083;F:growth factor activity;IDA:UniProtKB.

GO-P

GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0007275;P:multicellular organismal development;IEA:UniProtKB-KW. GO:0030308;P:negative regulation of cell growth;IDA:UniProtKB.