HuLPr29052

Uniprot ID

OSMR_HUMAN

Uniprot Acc

Q99650;Q6P4E8;Q96QJ6;

Protein name

Oncostatin-M-specific receptor subunit beta

Comment

FUNCTION:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.||SUBUNIT:Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99650-1; Sequence=Displayed; Name=2; IsoId=Q99650-2; Sequence=VSP 021527, VSP 021528;||TISSUE SPECIFICITY:Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.||INDUCTION:Activated by oncostatin-M. Up-regulated by IFNG/IFN- gamma and bacterial lipopolysaccharides (LPS).||DOMAIN:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding (By similarity).||DOMAIN:The box 1 moti

Subcellular localization

Membrane;Single-pass type I membrane protein(Potential).

Gene name

oncostatin M receptor

Protein sequence

MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVS TNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNV IWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLV DDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKL VEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVT AFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSK VLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQS YTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAE NYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMT WKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFL SELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAP SEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYN VVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIA NNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSW KPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVI STDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAP SDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYL KSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDN LKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMLI HILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSS ILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQF LGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENL TYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALE KNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPV EAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC

Database cross reference

RefSeq Protein accession:NP_001161827
RefSeq Protein gi:270288820

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005900;C:oncostatin-M receptor complex;IDA:BHF-UCL.

GO-F

GO:0019838;F:growth factor binding;IPI:BHF-UCL. GO:0004924;F:oncostatin-M receptor activity;TAS:ProtInc.

GO-P

GO:0008283;P:cell proliferation;TAS:ProtInc. GO:0002675;P:positive regulation of acute inflammatory response;IC:BHF-UCL. GO:0008284;P:positive regulation of cell proliferation;IGI:BHF-UCL.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr29052

PHOSPHORYLATION

826

S

Phospho-ELM

38496

HTP

N

HuLPr29052

PHOSPHORYLATION

828

T

Phospho-ELM

38498

HTP

N

HuLPr29052

PHOSPHORYLATION

830

T

Phospho-ELM

38499

HTP

N

HuLPr29052

PHOSPHORYLATION

837

Y

Phospho-ELM

22080

HTP

N

HuLPr29052

PHOSPHORYLATION

889

S

Phospho-ELM

38497

HTP

N

HuLPr29052

PHOSPHORYLATION

917

Y

PhosphoSitePlus

1930200

LTP

N

HuLPr29052

PHOSPHORYLATION

901

Y

PhosphoSitePlus

1930201

LTP

N

HuLPr29052

PHOSPHORYLATION

945

Y

PhosphoSitePlus

1930202

LTP

N

HuLPr29052

PHOSPHORYLATION

826

S

PhosphoSitePlus

3210450

LTP

N

HuLPr29052

PHOSPHORYLATION

889

S

PhosphoSitePlus

3210453

LTP

N

HuLPr29052

PHOSPHORYLATION

382

S

PhosphoSitePlus

18013381

LTP

N

HuLPr29052

PHOSPHORYLATION

978

Y

PhosphoSitePlus

455182

HTP

N

HuLPr29052

PHOSPHORYLATION

839

Y

PhosphoSitePlus

475364

HTP

N

HuLPr29052

PHOSPHORYLATION

861

Y

PhosphoSitePlus

458403

LTP

N

HuLPr29052

PHOSPHORYLATION

689

Y

PhosphoSitePlus

462478

LTP

HTP

N

HuLPr29052

PHOSPHORYLATION

837

Y

PhosphoSitePlus

462479

LTP

N

HuLPr29052

PHOSPHORYLATION

168

Y

PhosphoSitePlus

990934

LTP

N

HuLPr29052

PHOSPHORYLATION

180

Y

PhosphoSitePlus

990938

LTP

N

JAK-STAT