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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr29059

Uniprot ID

OSTCN_HUMAN

Uniprot Acc

P02818;Q5TCK6;

Protein name

Osteocalcin

Comment

FUNCTION:Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.||SUBCELLULAR LOCATION:Secreted.||PTM:Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.||SIMILARITY:Belongs to the osteocalcin/matrix Gla protein family.||SIMILARITY:Contains 1 Gla (gamma-carboxy-glutamate) domain.||WEB RESOURCE:Name=Wikipedia; Note=Osteocalcin entry; URL="http://en.wikipedia.org/wiki/Osteocalcin";||WEB RESOURCE:Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/bglap/";

Subcellular localization

Secreted.

Gene name

bone gamma-carboxyglutamate (gla) protein

Protein sequence

MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQ EGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPD CDELADHIGFQEAYRRFYGPV

Database cross reference

RefSeq Protein accession:NP_954642
RefSeq Protein gi:40316933

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0046848;F:hydroxyapatite binding;NAS:UniProtKB. GO:0008147;F:structural constituent of bone;NAS:UniProtKB.

GO-P

GO:0030282;P:bone mineralization;NAS:UniProtKB. GO:0007155;P:cell adhesion;NAS:UniProtKB. GO:0042476;P:odontogenesis;NAS:UniProtKB. GO:0030500;P:regulation of bone mineralization;IEA:InterPro. GO:0045124;P:regulation of bone resorption;NAS:UniProtKB.

Pathway

Pathway name

FGF_signaling_pathway

Pathway name

Validated_transcriptional_targets_of_AP1_family_members_Fra1_and_Fra2

Pathway name

Notch-mediated_HES/HEY_network

Pathway name

Regulation_of_retinoblastoma_protein

Pathway name

Glucocorticoid_receptor_regulatory_network

Pathway name

Leptin