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Protein basic information

LiverAtlas Protein ID

HuLPr29102

Uniprot ID

OXLA_HUMAN

Uniprot Acc

Q96RQ9;Q4GZN1;Q4GZN2;Q6P2Q3;Q8TEM5;Q96RQ8;

Protein name

L-amino-acid oxidase

Comment

FUNCTION:Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).||CATALYTIC ACTIVITY:An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).||COFACTOR:FAD (By similarity).||SUBCELLULAR LOCATION:Isoform 1:Lysosome (By similarity).||SUBCELLULAR LOCATION:Isoform 2:Lysosome (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative promoter usage, Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96RQ9-1; Sequence=Displayed; Name=2; Synonyms=IL4I1 2; IsoId=Q96RQ9-2; Sequence=VSP 017173; Note=Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62;||TISSUE SPECIFICITY:Isoform 1 is primarily found in immune tissues.||INDUCTION:By IL4/interleukin-4.||SIMILARITY:Belongs to the flavin monoamine oxidase family. FIG1 subfamily.||SEQUENCE CAUTION:Sequence=BAB84923.1; Type=Erroneous initiation; Sequence=CAI54291.1; Type=Erroneous in

Subcellular localization

Isoform 1:Lysosome(By similarity).

Gene name

interleukin 4 induced 1

Protein sequence

MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDP DYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLS DAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMP SSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNY VVEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKA LGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSE DGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALL SSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVL KADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPA TKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREG ALLLASYTWSDAAAAFAGLSREEALRLALDDVAALHGPV VRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDW TVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRK GPASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGS HPPVQGQLSLQNTTHTRTSH

Database cross reference

RefSeq Protein accession:NP_690863
RefSeq Protein gi:23821023

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005764;C:lysosome;IEA:UniProtKB-SubCell.

GO-F

GO:0001716;F:L-amino-acid oxidase activity;IEA:EC.

Pathway

Pathway name

Phenylalanine_and_Tyrosine_Metabolism

Pathway name

Aspartate_Metabolism