HuLPr29143

Uniprot ID

P3H2_HUMAN

Uniprot Acc

Q8IVL5;B3KWI9;Q9NVI2;

Protein name

Prolyl 3-hydroxylase 2

Comment

FUNCTION:Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V (By similarity).||CATALYTIC ACTIVITY:L-proline-[procollagen] + 2-oxoglutarate + O(2) = trans-3-hydroxy-L-proline-[procollagen] + succinate + CO(2).||COFACTOR:Iron (By similarity).||COFACTOR:Ascorbate (By similarity).||SUBCELLULAR LOCATION:Endoplasmic reticulum. Golgi apparatus.||TISSUE SPECIFICITY:Expressed in heart, placenta, lung, liver, skeletal muscle and kidney. Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells.||SIMILARITY:Belongs to the leprecan family.||SIMILARITY:Contains 1 Fe2OG dioxygenase domain.||SIMILARITY:Contains 4 TPR repeats.||SEQUENCE CAUTION:Sequence=BAA91769.1; Type=Erroneous initiation;

Subcellular localization

Endoplasmic reticulum.Golgi apparatus.

Gene name

leprecan-like 1

Protein sequence

MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGP LQPFDLLYASGAAAYYSGDYERAVRDLEAALRSHRRLRE IRTRCARHCAARHPLPPPPPGEGPGAELPLFRSLLGRAR CYRSCETQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRA YIKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAG VEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQ ALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIA DHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQ FAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESL LDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGF SYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKK LSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDN VLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEG ATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFM LNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLL DPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEM DAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCA VALWFTLDPLYRELERIQADEVIAILDQEQQGKHELNINPKDEL

Database cross reference

RefSeq Protein accession:NP_001127890
RefSeq Protein gi:197313662

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005783;C:endoplasmic reticulum;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell.

GO-F

GO:0005506;F:iron ion binding;IEA:InterPro. GO:0031418;F:L-ascorbic acid binding;IEA:UniProtKB-KW. GO:0016702;F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;IEA:UniProtKB-KW

GO-P

GO:0008285;P:negative regulation of cell proliferation;IDA:UniProtKB. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.