HuLPr29148

Uniprot ID

P4HA3_HUMAN

Uniprot Acc

Q7Z4N8;A0AV13;Q5EBL3;Q5JPA9;

Protein name

Prolyl 4-hydroxylase subunit alpha-3

Comment

FUNCTION:Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.||CATALYTIC ACTIVITY:L-proline-[procollagen] + 2-oxoglutarate + O(2) = trans-4-hydroxy-L-proline-[procollagen] + succinate + CO(2).||COFACTOR:Binds 1 Fe(2+) ion per subunit.||COFACTOR:Ascorbate.||SUBUNIT:Heterotetramer of two alpha-3 chains and two beta chains (the beta chain is the multi-functional PDI).||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z4N8-1; Sequence=Displayed; Name=2; IsoId=Q7Z4N8-2; Sequence=VSP 031146, VSP 031147; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions.||PTM:N-glycosylation plays no role in the

Subcellular localization

Endoplasmic reticulum lumen(Probable).

Gene name

prolyl 4-hydroxylase, alpha polypeptide III

Protein sequence

MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARA LAPERRLLGLLRRYLRGEEARLRDLTRFYDKVLSLHEDS TTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKD GYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARG VFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGD YYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAF AYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLL AESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPT LYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYH DFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISK SAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVN YGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSS VEAGGATAFIYANLSVPVVRNAALFWWNLHRSGEGDSDT LHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED

Database cross reference

RefSeq Protein accession:NP_878907
RefSeq Protein gi:33589818

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

GO:0005788;C:endoplasmic reticulum lumen;IEA:UniProtKB-SubCell.

GO-F

GO:0005506;F:iron ion binding;IEA:InterPro. GO:0031418;F:L-ascorbic acid binding;IEA:UniProtKB-KW. GO:0016702;F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;IEA:UniProtKB-KW

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr29148

PHOSPHORYLATION

171

Y

PhosphoSitePlus

1005201

LTP

N

Arginine_and_Proline_Metabolism

Prolidase_Deficiency(PD)