Protein basic information
| LiverAtlas Protein ID |
HuLPr29150 |
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Uniprot ID |
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Uniprot Acc |
Q9BTU6;D3DR59;Q9NSG8; |
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Protein name |
Phosphatidylinositol 4-kinase type 2-alpha |
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Comment |
FUNCTION:Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity).||CATALYTIC ACTIVITY:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.||SUBCELLULAR LOCATION:Cytoplasm. Membrane raft. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts.||TISSUE SPECIFICITY:Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine.||SIMILARITY:Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.||SIMILARITY:Contains 1 PI3K/PI4K domain. |
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Subcellular localization |
Cytoplasm.Membrane raft. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAA AAGSGPSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAA QAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAE LAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEE PYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGA SLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKR LALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWL RRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDN WLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFP LKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDP NFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNL TQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW |
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Database cross reference |
RefSeq Protein accession:NP_060895
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;IDA:UniProtKB. GO:0045121;C:membrane raft;IDA:UniProtKB. |
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GO-F |
GO:0004430;F:1-phosphatidylinositol 4-kinase activity;IDA:UniProtKB. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0000287;F:magnesium ion binding;NAS:UniProtKB. |
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GO-P |
GO:0006661;P:phosphatidylinositol biosynthetic process;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr29150 |
PHOSPHORYLATION |
462 |
S |
Phospho-ELM |
HTP |
yes |
 
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|
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HuLPr29150 |
PHOSPHORYLATION |
44 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29150 |
PHOSPHORYLATION |
460 |
S |
Phospho-ELM |
HTP |
yes |
|
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HuLPr29150 |
PHOSPHORYLATION |
47 |
S |
Phospho-ELM |
HTP |
yes |
|
|
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HuLPr29150 |
PHOSPHORYLATION |
5 |
S |
Phospho-ELM |
HTP |
N |
|
|
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HuLPr29150 |
PHOSPHORYLATION |
51 |
S |
Phospho-ELM |
HTP |
yes |
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HuLPr29150 |
PHOSPHORYLATION |
9 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr29150 |
PHOSPHORYLATION |
44 |
S |
PhosphoSitePlus |
HTP |
N |
|
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HuLPr29150 |
PHOSPHORYLATION |
460 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr29150 |
PHOSPHORYLATION |
138 |
Y |
PhosphoSitePlus |
LTP |
N |
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HuLPr29150 |
PHOSPHORYLATION |
5 |
S |
PhosphoSitePlus |
HTP |
N |
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HuLPr29150 |
PHOSPHORYLATION |
9 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr29150 |
PHOSPHORYLATION |
464 |
S |
PhosphoSitePlus |
HTP |
N |
|
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HuLPr29150 |
PHOSPHORYLATION |
47 |
S |
PhosphoSitePlus |
LTP |
yes |
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HuLPr29150 |
PHOSPHORYLATION |
51 |
S |
PhosphoSitePlus |
LTP |
yes |
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HuLPr29150 |
PHOSPHORYLATION |
466 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29150 |
PHOSPHORYLATION |
462 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
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HuLPr29150 |
PHOSPHORYLATION |
18 |
Y |
PhosphoSitePlus |
LTP |
N |
|
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HuLPr29150 |
PHOSPHORYLATION |
461 |
S |
PhosphoSitePlus |
HTP |
N |
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Pathway
| Pathway name |
