HuLPr29152

Uniprot ID

P4R3A_HUMAN

Uniprot Acc

Q6IN85;Q69YK6;Q86U23;Q86YI7;Q8IVG1;Q9H3F1;Q9H7U8;Q9NV01;Q9NWP1;

Protein name

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Comment

FUNCTION:Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.||SUBUNIT:Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.||INTERACTION:P60510:PPP4C; NbExp=1; IntAct=EBI-1055598, EBI-1046072;||SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6IN85-1; Sequence=Displayed; Note=No experiment

Subcellular localization

Cytoplasm.Cytoplasm, cytoskeleton, centrosome.Nucleus.

Gene name

SMEK homolog 1, suppressor of mek1 (Dictyostelium)

Protein sequence

MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSL LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYD LALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESE EERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRR EKLALALENEGYIKKLLELFHVCEDLENIEGLHHLYEII KGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRK HREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMV LPTPSVFEENMLSTLHSFIFFNKVEIVGMLQEDEKFLTD LFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNRDA FFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEY NPSMVREFVMQEAQQNDDVSKKLTEQKITSKDILLINLI IEHMICDTDPELGGAVQLMGLLRTLVDPENMLATANKTE KTEFLGFFYKHCMHVLTAPLLANTTEDKPSKDDFQTAQL LALVLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASK HAFLALCALRFKRKIIGLKDEFYNRYIMKSFLFEPVVKA FLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENYW KALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILR NHRYRRDARTLEDEEEMWFNTDEDDMEDGEAVVSPSDKT KNDDDIMDPISKFMERKKLKESEEKEVLLKTNLSGRQSP SFKLSLSSGTKTNLTSQSSTTNLPGSPGSPGSPGSPGSP GSVPKNTSQTAAITTKGGLVGLVDYPDDDEDDDEDEDKEDTLPLSKKAKFDS

Database cross reference

RefSeq Protein accession:NP_115949
RefSeq Protein gi:31657117

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005815;C:microtubule organizing center;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005515;F:protein binding;IPI:IntAct.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr29152

PHOSPHORYLATION

777

S

Phospho-ELM

5944

HTP

N

HuLPr29152

PHOSPHORYLATION

117

S

Phospho-ELM

36140

HTP

N

HuLPr29152

PHOSPHORYLATION

127

S

Phospho-ELM

36141

HTP

N

HuLPr29152

PHOSPHORYLATION

698

S

Phospho-ELM

36142

HTP

N

HuLPr29152

PHOSPHORYLATION

768

S

Phospho-ELM

36143

HTP

N

HuLPr29152

PHOSPHORYLATION

771

S

Phospho-ELM

36144

HTP

N

HuLPr29152

PHOSPHORYLATION

774

S

Phospho-ELM

36145

HTP

N

HuLPr29152

PHOSPHORYLATION

780

S

Phospho-ELM

36146

HTP

N

HuLPr29152

PHOSPHORYLATION

783

S

Phospho-ELM

36147

HTP

N

HuLPr29152

PHOSPHORYLATION

777

S

PhosphoSitePlus

449159

LTP

HTP

N

HuLPr29152

ACETYLATION

655

K

PhosphoSitePlus

11317191

LTP

N

HuLPr29152

PHOSPHORYLATION

768

S

PhosphoSitePlus

472191

HTP

N

HuLPr29152

PHOSPHORYLATION

117

S

PhosphoSitePlus

3202452

HTP

N

HuLPr29152

PHOSPHORYLATION

127

S

PhosphoSitePlus

3202455

LTP

N

HuLPr29152

PHOSPHORYLATION

698

S

PhosphoSitePlus

3202458

LTP

HTP

N

HuLPr29152

PHOSPHORYLATION

771

S

PhosphoSitePlus

3202461

LTP

N

HuLPr29152

PHOSPHORYLATION

741

S

PhosphoSitePlus

476352

LTP

HTP

N

HuLPr29152

PHOSPHORYLATION

169

Y

PhosphoSitePlus

465389

LTP

N

HuLPr29152

PHOSPHORYLATION

685

T

PhosphoSitePlus

471765

HTP

N

HuLPr29152

PHOSPHORYLATION

774

S

PhosphoSitePlus

467862

HTP

N

HuLPr29152

PHOSPHORYLATION

780

S

PhosphoSitePlus

467863

LTP

N

Ins/IGF