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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr29210

Uniprot ID

PA24B_HUMAN

Uniprot Acc

P0C869;B4DRT9;O95712;Q19KD5;Q19KD6;Q59GF9;Q8TB10;Q9UKV7;

Protein name

Cytosolic phospholipase A2 beta

Comment

FUNCTION:Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.||CATALYTIC ACTIVITY:Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.||ENZYME REGULATION:Stimulated by cytosolic Ca(2+).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: Vmax=7.9 pmol/min/mg enzyme (isoform 5); Vmax=3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4); Vmax=140 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5); Vmax=1.6 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3); Vmax=2.1 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5); Vmax=0.6 nmol/min/ug enzyme with 1-16:0-2-[14C]20:

Subcellular localization

Cytoplasm, cytosol.

Gene name

JMJD7-PLA2G4B readthrough

Protein sequence

MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLP TACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELK VFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQG EGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLE ETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPA CWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQ EPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQV VAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLY GQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQ KDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERAR LGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQ NPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGA FIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAAN LQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPP STAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQH PHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCL PLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIP FPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSD SFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYS QEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH

Database cross reference

RefSeq Protein accession:NP_001185517
RefSeq Protein gi:310703680

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005829;C:cytosol;IDA:UniProtKB. GO:0031901;C:early endosome membrane;IEA:UniProtKB-SubCell. GO:0005576;C:extracellular region;TAS:UniProtKB. GO:0031966;C:mitochondrial membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005509;F:calcium ion binding;NAS:UniProtKB. GO:0047498;F:calcium-dependent phospholipase A2 activity;IDA:UniProtKB. GO:0005544;F:calcium-dependent phospholipid binding;NAS:UniProtKB. GO:0004622;F:lysophospholipase activity;NAS:UniProtKB.

GO-P

GO:0019369;P:arachidonic acid metabolic process;NAS:UniProtKB. GO:0019722;P:calcium-mediated signaling;NAS:UniProtKB. GO:0046475;P:glycerophospholipid catabolic process;IDA:UniProtKB. GO:0006954;P:inflammatory response;NAS:UniProtKB. GO:0007567;P:partu

Pathway

Pathway name

Alpha_Linolenic_Acid_and_Linoleic_Acid_Metabolism

Pathway name

Phospholipid_Biosynthesis