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Protein basic information

LiverAtlas Protein ID

HuLPr29285

Uniprot ID

PAOX_HUMAN

Uniprot Acc

Q6QHF9;D3DXI6;Q5VWY0;Q6QHF5;Q6QHF6;Q6QHF7;Q6QHF8;Q6QHG0;Q6QHG1;Q6QHG2;Q6QHG3;Q6QHG4;Q6QHG5;Q6QHG6;Q86WP9;Q8N555;Q8NCX3;

Protein name

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Comment

FUNCTION:Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity:N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.||CATALYTIC ACTIVITY:N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).||CATALYTIC ACTIVITY:N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).||CATALYTIC ACTIVITY:N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal + H(2)O(2).||COFACTOR:Binds 1 FAD per subunit (By similarity).||PATHWAY:Amine and polyamine metabolism; spermine metabolism.||SUBUNIT:Monomer (By similarity).||SU

Subcellular localization

Peroxisome(By similarity).Cytoplasm(By similarity).

Gene name

polyamine oxidase (exo-N4-amino)

Protein sequence

MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPH LRVLEATARAGGRIRSERCFGGVVEVGAHWIHGPSRGNP VFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASS GTSVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGE YLKKEIGQHVARLCGHSAFPHLRVLEATARAGGRIRSER CFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQ ENQLVETGGHVGLPSVSYASSGASVSLQLVAEMATLFYG LIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEE TRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVL PGLDCTFSKGYQGLTNCMMAALPEDTVVFEKPVKTIHWN GSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFL REHLDTFFDPPLPAEKAEAIRKIGFGTNNKIFLEFEEPF WEPDCQLIQLVWEDTSPLEDAAPELQDAWFRKLIGFVVL PAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRR VTGNPRLPAPKSVLRSRWHSAPYTRGSYSYVAVGSTGGD LDLLAQPLPADGAGAQLQILFAGEATHRTFYSTTHGALL SGWREADRLLSLWAPQVQQPRPRL

Database cross reference

RefSeq Protein accession:NP_690875
RefSeq Protein gi:23097272

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005782;C:peroxisomal matrix;EXP:Reactome.

GO-F

GO:0046592;F:polyamine oxidase activity;EXP:Reactome.

GO-P

GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0006596;P:polyamine biosynthetic process;TAS:Reactome. GO:0006805;P:xenobiotic metabolic process;TAS:Reactome.

Pathway

Pathway name

Alpha9_beta1_integrin_signaling_events