HuLPr29309

Uniprot ID

PAR14_HUMAN

Uniprot Acc

Q460N5;B4E2H0;Q460N4;Q8J027;Q9H9X9;Q9NV60;Q9ULF2;

Protein name

Poly [ADP-ribose] polymerase 14

Comment

FUNCTION:Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.||CATALYTIC ACTIVITY:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.||SUBUNIT:Interacts with STAT6 (By similarity).||SUBCELLULAR LOCATION:Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=6; IsoId=Q460N5-6; Sequence=Displayed; Name=1; Synonyms=BAL2B; IsoId=Q460N5-1; Sequence=VSP 040876; Name=3; Synonyms=BAL2A; IsoId=Q460N5-3; Sequence=VSP 020014; Name=4; IsoId=Q460N5-4; Sequence=VSP 020018, VSP 020019; Name=5; IsoId=Q460N5-5; Sequence=VSP 020013, VSP 020017;||SIMILARITY:Contains 3 Macro domains.||SIMILARITY:Contains 1 PARP catalytic domain.||SIMILARITY:Contains 1 WWE domain.||SEQUENCE CAUTION:Sequence=AAY64449.1; Type=Erroneous initiation; Note=Translation N-terminally extended

Subcellular localization

Nucleus.Cytoplasm.

Gene name

poly (ADP-ribose) polymerase family, member 14

Protein sequence

MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGG ECEVRQDPRSPSRFLVFFYPEDVRQKVLERKNHELVWQG KGTFKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEP DVSEELDTKLPLDGGLDKMEDIPEECENISSLVAFENLK ANVTDIMLILLVENISGLSNDDFQVEIIRDFDVAVVTFQ KHIDTIRFVDDCTKHHSIKQLQLSPRLLEVTNTIRVENL PPGADDYSLKLFFENPYNGGGRVANVEYFPEESSALIEF FDRKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEK PLIKLPAPFEESLDLPLWKFLQKKNHLIEEINDEMRRCH CELTWSQLSGKVTIRPAATLVNEGRPRIKTWQADTSTTL SSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLK EMVILAGKSEDVQSIEVQVRELIESTTQKIKREEQSLKE KMIISPGRYFLLCHSSLLDHLLTECPEIEICYDRVTQHL CLKGPSADVYKAKCEIQEKVYTMAQKNIQVSPEIFQFLQ QVNWKEFSKCLFIAQKILALYELEGTTVLLTSCSSEALL EAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNLLKKQ NSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNF VEQNMKIERLVEVKPSLVIDYLKTEKKLFWPKIKKVNVQ VSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCVKS VHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVM KEGGSPAGQKCFSRTVLAPGVVLIVQQGDLARLPVDVVV NASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRL LPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLR RAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETI VSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKT VFKATLPDTAAPPGLPPAAAGPGK

Database cross reference

RefSeq Protein accession:NP_060024
RefSeq Protein gi:154813199

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IDA:HPA. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IDA:HPA.

GO-F

GO:0003950;F:NAD+ ADP-ribosyltransferase activity;IEA:EC.

GO-P

GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr29309

PHOSPHORYLATION

830

Y

PhosphoSitePlus

1007825

LTP

HTP

N

IL4-mediated_signaling_events