Protein basic information
| LiverAtlas Protein ID |
HuLPr29517 |
|
Uniprot ID |
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Uniprot Acc |
Q9GZP0;A8K9T6;Q9BWV5; |
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Protein name |
Platelet-derived growth factor D |
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Comment |
FUNCTION:Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet- derived growth factor receptor. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.||SUBUNIT:Homodimer; disulfide-linked.||SUBCELLULAR LOCATION:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long, SCDGF-B-L; IsoId=Q9GZP0-1; Sequence=Displayed; Name=2; Synonyms=Short, SCDGF-B-S; IsoId=Q9GZP0-2; Sequence=VSP 020615;||TISSUE SPECIFICITY:Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen |
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Subcellular localization |
Secreted. |
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Gene name |
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Protein sequence
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MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRR DESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLL TWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVED ISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYF VAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYN SPSVTDPTLIADALDKKIAEFDTVEDLLKYFNPESWQED LENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTP RNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNW RSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDI QLDHHERCDCICSSRPPR |
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Database cross reference |
RefSeq Protein accession:NP_079484
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005788;C:endoplasmic reticulum lumen;TAS:Reactome. GO:0005576;C:extracellular region;EXP:Reactome. GO:0000139;C:Golgi membrane;EXP:Reactome. |
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GO-F |
GO:0008083;F:growth factor activity;IEA:UniProtKB-KW. |
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GO-P |
GO:0051781;P:positive regulation of cell division;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29517 |
PHOSPHORYLATION |
327 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name |
Urokinase-type_plasminogen_activator_(uPA)_and_uPAR-mediated_signaling |
| Pathway name |
