HuLPr29548

Uniprot ID

PDX1_HUMAN

Uniprot Acc

P52945;O60594;Q5VYW2;

Protein name

Pancreas/duodenum homeobox protein 1

Comment

FUNCTION:Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.||SUBUNIT:Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7.||SUBCELLULAR LOCATION:Nucleus.||TISSUE SPECIFICITY:Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).||DOMAIN:The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By similarit

Subcellular localization

Nucleus.

Gene name

pancreatic and duodenal homeobox 1

Protein sequence

MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGR QPPPPPPHPFPGALGALEQGSPPDISPYEVPPLADDPAV AHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLP FPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQ LLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQN RRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEEL LALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSV APRRPQEPR

Database cross reference

RefSeq Protein accession:NP_000200
RefSeq Protein gi:4557673

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003700;F:sequence-specific DNA binding transcription factor activity;TAS:BHF-UCL. GO:0003704;F:specific RNA polymerase II transcription factor activity;TAS:ProtInc.

GO-P

GO:0051594;P:detection of glucose;ISS:BHF-UCL. GO:0006091;P:generation of precursor metabolites and energy;TAS:ProtInc. GO:0030073;P:insulin secretion;IDA:BHF-UCL. GO:0007263;P:nitric oxide mediated signal transduction;IDA:BHF-UCL. GO:0009887;P:organ m

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr29548

PHOSPHORYLATION

61

S

PhosphoSitePlus

458401

LTP

HTP

N

HuLPr29548

PHOSPHORYLATION

66

S

PhosphoSitePlus

458402

HTP

N

HuLPr29548

PHOSPHORYLATION

11

T

PhosphoSitePlus

456815

LTP

N

FOXA2_and_FOXA3_transcription_factor_networks