HuLPr29556

Uniprot ID

PDZD2_HUMAN

Uniprot Acc

O15018;Q9BXD4;

Protein name

PDZ domain-containing protein 2

Comment

SUBUNIT:Interacts with SCN10A, CTNND2 and PKP4 (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity). Cytoplasm. Endoplasmic reticulum. Note=At cell-cell contacts in lung epithelial cells (By similarity).||SUBCELLULAR LOCATION:Processed PDZ domain-containing protein 2:Secreted (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15018-1; Sequence=Displayed; Name=2; IsoId=O15018-2; Sequence=VSP 012369, VSP 012370, VSP 012371, VSP 012372, VSP 012373; Note=May be due to aberrant splicing;||TISSUE SPECIFICITY:Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.||PTM:A secreted form is produced by caspase-mediated proteolytic cleavage (By similarity).||SIMILARITY:Contains 6 PDZ (DHR) domains.||SEQUENCE CAUTION:Sequence=BAA20760.2; Type=Erroneous initiation;

Subcellular localization

Nucleus(By similarity).Cytoplasm.Endoplasmic reticulum.

Gene name

PDZ domain containing 2

Protein sequence

MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQ KLQEYIQLNFAVDESTVPPDHSPPEMEICTVYLTKELGD TETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGC IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSG ASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSE PGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESK GSAGCEVSSDPSTELENGPDPELGNGHVFQLENGPDSLK EVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKG GKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGR GSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL LVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTS KSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRA MPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGG VHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQL LDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISI IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSA AEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGL FVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA GGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIG ACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEV NSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSE QEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSL ISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTS EEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQV TVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEF DREGDCISLPGALPGPIRPLSEDD

Database cross reference

RefSeq Protein accession:NP_835260
RefSeq Protein gi:87196343

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005911;C:cell-cell junction;ISS:UniProtKB. GO:0005783;C:endoplasmic reticulum;ISS:UniProtKB. GO:0005576;C:extracellular region;ISS:UniProtKB. GO:0005634;C:nucleus;ISS:UniProtKB.

GO-P

GO:0007155;P:cell adhesion;IEA:UniProtKB-KW.

TNFalpha