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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr29598

Uniprot ID

PERP_HUMAN

Uniprot Acc

Q96FX8;E1P590;Q8IWS3;Q8N1J6;Q8NC16;Q9H1C5;Q9H230;

Protein name

p53 apoptosis effector related to PMP-22

Comment

FUNCTION:Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).||SUBCELLULAR LOCATION:Cell junction, desmosome. Cell membrane; Multi-pass membrane protein (By similarity). Note=Associated with desmosomes (By similarity).||TISSUE SPECIFICITY:Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.||SIMILARITY:Belongs to the TMEM47 family.

Subcellular localization

Cell junction, desmosome.Cell membrane;Multi-pass membrane protein(By similarity).

Gene name

PERP, TP53 apoptosis effector

Protein sequence

MIRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSD HGQTSSLWWKCSQEGGGSGSYEEGCQSLMEYAWGRAAAA MLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALA AVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGW AATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA

Database cross reference

RefSeq Protein accession:NP_071404
RefSeq Protein gi:31377722

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0030057;C:desmosome;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IDA:HPA. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005634;C:nucleus;IDA:HPA.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0007155;P:cell adhesion;IEA:UniProtKB-KW.

Pathway

Pathway name

Validated_transcriptional_targets_of_deltaNp63_isoforms

Pathway name

Direct_p53_effectors

Pathway name

Validated_transcriptional_targets_of_TAp63_isoforms

Pathway name

TCR