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Protein basic information

LiverAtlas Protein ID

HuLPr29627

Uniprot ID

PG12A_HUMAN

Uniprot Acc

Q9BZM1;Q9BZ89;

Protein name

Group XIIA secretory phospholipase A2

Comment

FUNCTION:PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine.||CATALYTIC ACTIVITY:Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.||COFACTOR:Binds 1 calcium ion per subunit (By similarity).||SUBCELLULAR LOCATION:Secreted. Cytoplasm.||TISSUE SPECIFICITY:Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.||MASS SPECTROMETRY:Mass=18702.6; Mass error=0.5; Method=MALDI; Range=22-189; Source=PubMed:11031251;||SIMILARITY:Belongs to the phospholipase A2 family.

Subcellular localization

Secreted.Cytoplasm.

Gene name

phospholipase A2, group XIIA

Protein sequence

MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRN GVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGY KPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCG KSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVE LLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL

Database cross reference

RefSeq Protein accession:NP_110448
RefSeq Protein gi:21361944

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;NAS:UniProtKB.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0047498;F:calcium-dependent phospholipase A2 activity;NAS:UniProtKB.

GO-P

GO:0016042;P:lipid catabolic process;IEA:UniProtKB-KW. GO:0006644;P:phospholipid metabolic process;IEA:InterPro.