Protein basic information
| LiverAtlas Protein ID |
HuLPr29641 |
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Uniprot ID |
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Uniprot Acc |
P98160;Q16287;Q5SZI3;Q9H3V5; |
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Protein name |
Basement membrane-specific heparan sulfate proteoglycan core protein |
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Comment |
FUNCTION:Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.||FUNCTION:Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated ac |
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Subcellular localization |
Secreted, extracellular space, extracellular matrix, basement membrane. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIET VTASQMRWTHSYLSDDEDMLADSISGDDLGSGDLGSGDF QMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDT LESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNAD GAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFP RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE EPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQP LLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDG SDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCED RTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEE SDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVA IGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDV KESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDG HFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQP DDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLS RRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELARG MLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQF SEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMA SVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSC ESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCL NCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYID ASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYE GNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNV VGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSS WSRAQLHGASEEPGHFSLTNAASTHTTNEGIFSPTPGEL GFSSFHRLLSGPYFWSLPSRFLGD |
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Database cross reference |
RefSeq Protein accession:NP_005520
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005604;C:basement membrane;IEA:UniProtKB-SubCell. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005886;C:plasma membrane;TAS:Reactome. |
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GO-F |
GO:0008022;F:protein C-terminus binding;IPI:UniProtKB. |
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GO-P |
GO:0001525;P:angiogenesis;IEA:UniProtKB-KW. GO:0007155;P:cell adhesion;IEA:InterPro. GO:0006629;P:lipid metabolic process;TAS:Reactome. GO:0042157;P:lipoprotein metabolic process;TAS:Re |