Protein basic information
| LiverAtlas Protein ID |
HuLPr29708 |
|
Uniprot ID |
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Uniprot Acc |
Q86SQ0;A5PKZ3;Q59EA8;Q68CY3;Q6NT98;Q8N8U8;Q8NAB1;Q8NCU5; |
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Protein name |
Pleckstrin homology-like domain family B member 2 |
|
Comment |
FUNCTION:Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).||SUBUNIT:Interacts with FLNC.||SUBCELLULAR LOCATION:Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86SQ0-1; Sequence=Displayed; Name=2; IsoId=Q86SQ0-2; Sequence=VSP 016745; Name=3; IsoId=Q86SQ0-3; Sequence=VSP 016744, VSP 016745;||DOMAIN:The PH domain mediates the binding to phosphoinositides.||SIMILARITY:Contains 1 PH domain.||SEQUENCE CAUTION:Sequence=AAH69194.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAD93140.1; Type=Erroneous initiation; |
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Subcellular localization |
Cytoplasm.Membrane;Peripheral membrane protein. |
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Gene name |
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Protein sequence
|
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSP KKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSV RSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSL SGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKS HDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRS GAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENIN LRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPP RNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALP YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASD DFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFD EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHR RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRC HRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL TRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDME CALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE KTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQ LQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKEN LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR EQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGF PVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADA VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT LPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGS VLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN RTASESNVYLNSFHYPDHSYKDQA |
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Database cross reference |
RefSeq Protein accession:NP_001127909
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:HPA. GO:0045111;C:intermediate filament cytoskeleton;IDA:HPA. GO:0005886;C:plasma membrane;IDA:HPA. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29708 |
PHOSPHORYLATION |
157 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
162 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
212 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
244 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
308 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
309 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
334 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
347 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
348 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
351 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
384 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
387 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
404 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
414 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
415 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
417 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
468 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
493 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
501 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
513 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
521 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
524 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
526 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
550 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
565 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
574 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
71 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
73 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
898 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
909 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
489 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
574 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
465 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
504 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
71 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
73 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
241 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
242 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
557 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
982 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
243 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
244 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
245 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
ACETYLATION |
285 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
334 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
252 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
324 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
468 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
513 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
157 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
212 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
351 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
384 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
387 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
415 |
S |
PhosphoSitePlus |
LTP HTP |
yes |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
493 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
501 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
565 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
909 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
550 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
898 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
932 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
894 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
255 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
162 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
301 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
55 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
567 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
59 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
404 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
131 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29708 |
PHOSPHORYLATION |
489 |
S |
PhosphoSitePlus |
LTP |
yes |
|
Pathway
| Pathway name | |
| Pathway name |
