Protein basic information
| LiverAtlas Protein ID |
HuLPr29733 |
|
Uniprot ID |
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Uniprot Acc |
P48426;B0YJ66;D3DRV1;P53807;Q5VUX3; |
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Protein name |
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha |
|
Comment |
FUNCTION:Catalyzes the phosphorylation of phosphatidylinositol-5- phosphate on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate.||CATALYTIC ACTIVITY:ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.||SUBUNIT:Homodimer (By similarity).||TISSUE SPECIFICITY:Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.||SIMILARITY:Contains 1 PIPK domain.||CAUTION:This protein was previously thought to be a phosphatidylinositol-4-phosphate 5-kinase. |
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Gene name |
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Protein sequence
|
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSV LMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLF NKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTR SAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHN ILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVT RNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKD NDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDY SLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTP PDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEV YFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPE QYSKRFLDFIGHILT |
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Database cross reference |
RefSeq Protein accession:NP_005019
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
|
GO-F |
GO:0016308;F:1-phosphatidylinositol-4-phosphate 5-kinase activity;NAS:UniProtKB. GO:0016309;F:1-phosphatidylinositol-5-phosphate 4-kinase activity;IEA:EC. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29733 |
PHOSPHORYLATION |
93 |
Y |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
304 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
14 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29733 |
ACETYLATION |
145 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29733 |
ACETYLATION |
89 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
93 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
10 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
246 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
304 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
376 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29733 |
PHOSPHORYLATION |
3 |
T |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
