Protein basic information
| LiverAtlas Protein ID |
HuLPr29739 |
|
Uniprot ID |
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Uniprot Acc |
O14986;A8K9L9;P78518;P78519;Q5T5K6;Q5T5K8;Q5T5K9;Q5VZ00;Q7KYT5;Q8NHQ5;Q92749; |
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Protein name |
Phosphatidylinositol-4-phosphate 5-kinase type-1 beta |
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Comment |
FUNCTION:Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.||CATALYTIC ACTIVITY:ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.||SUBUNIT:Interacts with RAC1 (By similarity).||INTERACTION:O43791:SPOP; NbExp=1; IntAct=EBI-1053734, EBI-743549;||SUBCELLULAR LOCATION:Endomembrane system (By similarity). Note=Associated with membranes (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14986-1; Sequence=Displayed; Name=2; Synonyms=Isoform 1; IsoId=O14986-2; Sequence=VSP 016010, VSP 016011;||TISSUE SPECIFICITY:Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.||SIMILARITY:Contains 1 PIPK domain. |
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Subcellular localization |
Endomembrane system(By similarity). |
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Gene name |
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Protein sequence
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MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYT VGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYP DFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELS NPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYM NLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSM RMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMH EGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIH FLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQG PGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDIL QSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFM NSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQ EWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSL FEAASLATTISSSSLYVNEHYPHDRPTLYSNSKGLPSSS TFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL |
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Database cross reference |
RefSeq Protein accession:NP_003549
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0012505;C:endomembrane system;IEA:UniProtKB-SubCell. GO:0016020;C:membrane;IEA:UniProtKB-KW. GO:0001931;C:uropod;IDA:UniProtKB. |
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GO-F |
GO:0016308;F:1-phosphatidylinositol-4-phosphate 5-kinase activity;NAS:UniProtKB. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29739 |
PHOSPHORYLATION |
445 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
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HuLPr29739 |
PHOSPHORYLATION |
448 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29739 |
PHOSPHORYLATION |
105 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29739 |
PHOSPHORYLATION |
405 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
