Protein basic information
| LiverAtlas Protein ID |
HuLPr29751 |
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Uniprot ID |
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Uniprot Acc |
Q92508;A6NHT9;A7E2B7;Q0KKZ9; |
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Protein name |
Protein PIEZO1 |
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Comment |
FUNCTION:Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes.||MISCELLANEOUS:Piezo comes from the Greek 'piesi' meaning pressure.||SIMILARITY:Belongs to the PIEZO family. |
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Subcellular localization |
Endoplasmic reticulum membrane;Multi-pass membrane protein.Endoplasmic reticulum-Golgi intermediate compartment membrane.Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MEPHVLGAVLYWLLLPCALLAACLLRFSGLSLVYLLFLLL LPWFPGPTRCGLQGHTGRLLRALLGLSLLFLVAHLALQI CLHIVPRLDQLLGPSCSRWETLSRHIGVTRLDLKDIPNA IRLVAPDLGILVVSSVCLGICGRLARNTRQSPHPRELDD DERDVDASPTAGLQEAATLAPTRRSRLAARFRVTAHWLL VAAGRVLAVTLLALAGIAHPSALSSVYLLLFLALCTWWA CHFPISTRGFSRLCVAVGCFGAGHLICLYCYQMPLAQAL LPPAGIWARVLGLKDFVGPTNCSSPHALVLNTGLDWPVY ASPGVLLLLCYATASLRKLRAYRPSGQRKEAAKGYEARE LELAELDQWPQERESDQHVVPTAPDTEADNCIVHELTGQ SSVLRRPVRPKRAEPREASPLHSLGHLIMDQSYVCALIA MMVWSITYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPC ILLYGMTLCCLRYVWAMDLRPELPTTLGPVSLRQLGLEH TRYPCLDLGAMLLYTLTFWLLLRQFVKEKLLKWAESPAA LTEVTVADTEPTRTQTLLQSLGELVKGVYAKYWIYVCAG MFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYSLWRKL LKAFWWLVVAYTMLVLIAVYTFQFQDFPAYWRNLTGFTD EQLGDLGLEQFSVSELFSSILVPGFFLLACILQLHYFHR PFMQLTDMEHVSLPGTRLPRWAHRQDAVSGTPLLREEQQ EHQQQQQEEEEEEEDSRDEGLGVATPHQATQVPEGAAKW GLVAERLLELAAGFSDVLSRVQVFLRRLLELHVFKLVAL YTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLST VWTCVIIVCKMLYQLKVVNPQEYSSNCTEPFPNSTNLLP TEISQSLLYRGPVDPANWFGVRKGFPNLGYIQNHLQVLL LLVFEAIVYRRQEHYRRQHQLAPLPAQAVFASGTRQQLD QDLLGCLKYFINFFFYKFGLEICF |
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Database cross reference |
RefSeq Protein accession:NP_001136336
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0033116;C:ER-Golgi intermediate compartment membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005216;F:ion channel activity;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr29751 |
PHOSPHORYLATION |
1215 |
S |
Phospho-ELM |
HTP |
N |
 
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HuLPr29751 |
PHOSPHORYLATION |
1190 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr29751 |
PHOSPHORYLATION |
1213 |
T |
Phospho-ELM |
HTP |
N |
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HuLPr29751 |
PHOSPHORYLATION |
1215 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr29751 |
PHOSPHORYLATION |
1423 |
T |
Phospho-ELM |
HTP |
N |
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HuLPr29751 |
PHOSPHORYLATION |
960 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr29751 |
PHOSPHORYLATION |
965 |
S |
Phospho-ELM |
HTP |
N |
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