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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr29790

Uniprot ID

PIPSL_HUMAN

Uniprot Acc

A2A3N6;Q6NUK8;

Protein name

Putative PIP5K1A and PSMD4-like protein

Comment

FUNCTION:Has negligeable PIP5 kinase activity. Binds to ubiquitinated proteins.||SUBCELLULAR LOCATION:Cytoplasm.||TISSUE SPECIFICITY:Testis-specific.||MISCELLANEOUS:PIPSL gene appeared in hominoids by L1-mediated retrotransposition in a hominoid ancestor of a readthrough, intergenically spliced transcript between the PIP5K1A and PSMD4 genes.||SIMILARITY:Contains 1 PIPK domain.||SIMILARITY:Contains 2 UIM (ubiquitin-interacting motif) repeats.||SIMILARITY:Contains 1 VWFA domain.||CAUTION:Could be the product of a pseudogene. Although transcribed, the gene is poorly translated probably due to a deletion in the regulatory region. PubMed:17623810 could not detect the protein by Western blot.

Subcellular localization

Cytoplasm.

Gene name

PIP5K1A and PSMD4-like, pseudogene

Protein sequence

MASEVPYASGMPIKKIGHRSVDSSGGTTSSALKGAIQLGI THTVGSLSTKPESDVLMQDFHMVESIFFPSEGSNLTPAH HYNAFRFKTYAPVAFRYFWELFGIRPDDYLYSLCSEPLI ELCSSGASGSLFYVSSDDEFIVKTVRHKEAEFLQKLLPG YYINLNQNPRTLLPKFYGLYCVQTGGKNIRIVVMNNLLP RSVKMHIKYDLKGSTYRRRASQKEREKPLPTFKDLDFLQ DIPDGLFLDADVHNALCKTLQRDCLVLQSFKIMDYSLLM SIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMES IQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDI LQSYRFVKKLEHSWKALIHDGDTVSVHRPGFYAEWFQRF MCNTVFKKIPLKPSPSKKLRSGSSFSQRAGSSGNSCITY QPLVSGEHKAQVTTKAEVEPGVHLGCPDVLPQTPPLEEI SEGSPTPDPSFSPLVEETLQMLTTSVDNSEYMGNGDFLP TRLQAQQDAVNTVCHSKTRSNPENNVGLITLDNDCEVLT TLTPDTGRILSKLHTVQPKGKITFCMGIHVAHLALKHRQ GNNHKIRIIAFVGNPVEDNEKNLVKLAKCLKKEKVNVDI INFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSL ADALISFPILAGEGGAMMGLGASDFEFGVDPSADPELAL VLRVFMEEQRQRQEEEARQAAAASAAEAGIATTGTEDSD DALLKMTISQQEFGHTGLPDLSSMTEEEKIVCAMQMSLQ GAEFGLAESADIDASSAMDTSEPAKEEDDYDVMQDPEFL QSVLENLPGVDPNNEAIRNAVGSLASQATKDSKKDKKEEDKK

Database cross reference


Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0016307;F:phosphatidylinositol phosphate kinase activity;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0006281;P:DNA repair;IEA:InterPro. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:InterPro.