Protein basic information
| LiverAtlas Protein ID |
HuLPr29833 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q96JA3;Q7Z5V8;Q9BU78;Q9H274;Q9H8Z7; |
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Protein name |
Pleckstrin homology domain-containing family A member 8 |
|
Comment |
FUNCTION:Involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. May play a role in ensuring the coordination of the budding and the fission reactions.||SUBUNIT:Interacts with phosphatidyl inositol 4-phosphate (PIP) and the GTPase ADP-ribosylation factor (ARF).||SUBCELLULAR LOCATION:Cytoplasm. Note=Localized to perinuclear structures in the trans-Golgi network (TGN).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96JA3-1; Sequence=Displayed; Name=2; IsoId=Q96JA3-2; Sequence=VSP 028545, VSP 028546; Note=No experimental confirmation available; Name=3; IsoId=Q96JA3-3; Sequence=VSP 028543, VSP 028544; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in kidney cell lines.||DOMAIN:Interacts with PIP and ARF via plekstrin homology domain.||SIMILARITY:Contains 1 PH domain.||SEQUENCE CAUTION:Sequence=AAG48267.1; Type=Erroneous initiation; Sequence=AAK55424.1; Type=Erroneous ter |
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Subcellular localization |
Cytoplasm. |
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Gene name |
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 |
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Protein sequence
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MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGC KGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVA ERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMS ELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKS TCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLK SSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEI LMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKED GMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFS TMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPT VFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVE ADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQ TALNNAYGKTLRQHHGWVVRGVFALALRATPSYEDFVAA LTVKEGDHRKEAFSIGMQRDLSLYLPAMKKQMAILDALYEVHGLESDEVV |
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Database cross reference |
RefSeq Protein accession:NP_001183955
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0051861;F:glycolipid binding;IEA:InterPro. GO:0017089;F:glycolipid transporter activity;IEA:InterPro. |
|
GO-P |
GO:0015031;P:protein transport;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29833 |
PHOSPHORYLATION |
420 |
T |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr29833 |
PHOSPHORYLATION |
153 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29833 |
PHOSPHORYLATION |
380 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr29833 |
PHOSPHORYLATION |
381 |
T |
PhosphoSitePlus |
LTP |
N |
|
