Protein basic information
| LiverAtlas Protein ID |
HuLPr29844 |
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Uniprot ID |
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Uniprot Acc |
Q3KR16;Q3SWR1;Q8N1P1;Q8WYY1;Q9H8F4;Q9NVK9; |
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Protein name |
Pleckstrin homology domain-containing family G member 6 |
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Comment |
FUNCTION:Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.||SUBUNIT:Interacts with MYH10. Interacts with ELMO1 and EZR (in an open conformation).||SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3KR16-1; Sequence=Displayed; Name=2; IsoI |
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Subcellular localization |
Cytoplasm.Cytoplasm, cytoskeleton, spindle.Cytoplasm, cytoskeleton, spindle pole.Cleavage furrow. |
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Gene name |
pleckstrin homology domain containing, family G (with RhoGef domain) member 6 |
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Protein sequence
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MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYP RGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEP EKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGM PRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQ ELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQR VGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETR ASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYA REQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHING QVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFS TLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYL FLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDP NSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQ AALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSL EGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLE LRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDP PTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADS AGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREI REELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV |
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Database cross reference |
RefSeq Protein accession:NP_001138328
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0032154;C:cleavage furrow;IEA:UniProtKB-SubCell. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0000922;C:spindle pole;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005096;F:GTPase activator activity;IEA:UniProtKB-KW. GO:0005089;F:Rho guanyl-nucleotide exchange factor activity;IEA:InterPro. |
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GO-P |
GO:0035023;P:regulation of Rho protein signal transduction;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr29844 |
PHOSPHORYLATION |
574 |
T |
PhosphoSitePlus |
HTP |
N |
 
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Pathway
| Pathway name |
