Protein basic information
| LiverAtlas Protein ID |
HuLPr29891 |
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Uniprot ID |
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Uniprot Acc |
Q8N3E9;Q8TEC1;Q8TF37;Q96FL6; |
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Protein name |
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 |
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Comment |
FUNCTION:Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.||CATALYTIC ACTIVITY:1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.||COFACTOR:Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain (Probable).||ENZYME REGULATION:Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=105.3 uM for PIP2; Vmax=28.5 umol/min/mg enzyme;||SUBCELLULAR LOCATION:Membrane; Peripheral membrane protein. C |
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Subcellular localization |
Membrane;Peripheral membrane protein.Cytoplasm.Cleavage furrow. |
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Gene name |
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Protein sequence
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MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSD GGTKRPGLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTW HKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVR EGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTA EEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADS NQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNN DRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPE LLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTL DGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSH NTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGG EPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSL ENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPS PEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEE EEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAP NAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVY PLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNA GRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSI QVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQE TDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDAT SPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQRS |
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Database cross reference |
RefSeq Protein accession:NP_588614
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0032154;C:cleavage furrow;IEA:UniProtKB-SubCell. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0016020;C:membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0004435;F:phosphatidylinositol phospholipase C activity;IEA:EC. GO:0004871;F:signal transducer activity;IEA:UniProtKB-KW. |
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GO-P |
GO:0035556;P:intracellular signal transduction;IEA:InterPro. GO:0016042;P:lipid catabolic process;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr29891 |
PHOSPHORYLATION |
105 |
S |
Phospho-ELM |
HTP |
N |
 
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HuLPr29891 |
PHOSPHORYLATION |
496 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr29891 |
PHOSPHORYLATION |
496 |
S |
PhosphoSitePlus |
LTP |
N |
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HuLPr29891 |
PHOSPHORYLATION |
200 |
S |
PhosphoSitePlus |
LTP |
yes |
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HuLPr29891 |
PHOSPHORYLATION |
105 |
S |
PhosphoSitePlus |
LTP |
N |
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HuLPr29891 |
PHOSPHORYLATION |
706 |
Y |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
