Protein basic information
| LiverAtlas Protein ID |
HuLPr29930 |
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Uniprot ID |
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Uniprot Acc |
P00747;Q15146;Q5TEH4;Q6PA00; |
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Protein name |
Plasminogen |
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Comment |
FUNCTION:Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.||FUNCTION:Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.||CATALYTIC ACTIVITY:Preferential cleavage:Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.||ENZYME REGULATION:Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptoki |
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Subcellular localization |
Secreted. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQ LGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAEN RKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKT KNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDN DPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGK ISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCR NPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQ CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPEN FPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSC DSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSST TTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPD ADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVL LPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQ EPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTN PRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCV AHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLE KSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRK DIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITG WGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQST ELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWG LGCARPNKPGVYVRVSRFVTWIEGVMRNN |
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Database cross reference |
RefSeq Protein accession:NP_000292
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005615;C:extracellular space;IDA:HGNC. GO:0031232;C:extrinsic to external side of plasma membrane;IDA:BHF-UCL. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome. |
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GO-F |
GO:0034185;F:apolipoprotein binding;IPI:BHF-UCL. GO:0043498;F:cell surface binding;IDA:BHF-UCL. GO:0004252;F:serine-type endopeptidase activity;IDA:BHF-UCL. |
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GO-P |
GO:0022617;P:extracellular matrix disassembly;IDA:BHF-UCL. GO:0042730;P:fibrinolysis;TAS:Reactome. GO:0008285;P:negative regulation of cell proliferation;TAS:ProtInc. GO:0010812;P:negative regulation of cell-substrate adhesion;IDA:BHF-UCL. GO:0051918;P |