HuLPr29940

Uniprot ID

PLPL6_HUMAN

Uniprot Acc

Q8IY17;A6NGQ0;O60859;Q86W58;Q9UG58;

Protein name

Neuropathy target esterase

Comment

FUNCTION:Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.||CATALYTIC ACTIVITY:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.||ENZYME REGULATION:Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino- terminal transmembrane segment.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IY17-1; Sequence=Displayed; Name=2; IsoId=Q8IY17-2; Sequence=VSP 026388; Name=3; IsoId=Q8IY17-3; Sequence=V

Subcellular localization

Endoplasmic reticulum membrane;Single-pass type I membrane protein;Cytoplasmic side.

Gene name

patatin-like phospholipase domain containing 6

Protein sequence

MGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGA QPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLRVPKT PAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSV SATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPA VLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFL ELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCL PGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTV SARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVR LQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRT SPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGD PVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMA YERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACE YSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMR IEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGC LHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFT LRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARM SPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGR LRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTV HAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKIL GNLQQLQGPFPAGSGLGVPPHSELTNPASNLATVAILPV CAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASA LDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCL RQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQLVLL HREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSP AKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGG GGARGCSHIGVLKALEEAGVPVDL

Database cross reference

RefSeq Protein accession:NP_001159583
RefSeq Protein gi:260656037

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004622;F:lysophospholipase activity;IEA:EC.

GO-P

GO:0008219;P:cell death;IEA:UniProtKB-KW. GO:0016042;P:lipid catabolic process;IEA:UniProtKB-KW. GO:0046470;P:phosphatidylcholine metabolic process;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr29940

PHOSPHORYLATION

352

T

Phospho-ELM

37070

HTP

N

HuLPr29940

PHOSPHORYLATION

353

S

Phospho-ELM

37069

HTP

N

HuLPr29940

PHOSPHORYLATION

345

S

Phospho-ELM

3234

HTP

N

HuLPr29940

PHOSPHORYLATION

411

S

PhosphoSitePlus

3831755

LTP

N

HuLPr29940

PHOSPHORYLATION

470

Y

PhosphoSitePlus

473196

LTP

HTP

N

HuLPr29940

PHOSPHORYLATION

363

S

PhosphoSitePlus

3842387

LTP

N

HuLPr29940

PHOSPHORYLATION

809

S

PhosphoSitePlus

11537698

LTP

HTP

N

HuLPr29940

PHOSPHORYLATION

353

S

PhosphoSitePlus

3205698

HTP

N

HuLPr29940

PHOSPHORYLATION

352

T

PhosphoSitePlus

3205701

HTP

N

HuLPr29940

PHOSPHORYLATION

1313

T

PhosphoSitePlus

471580

HTP

N

HuLPr29940

PHOSPHORYLATION

345

S

PhosphoSitePlus

453701

LTP

N

HuLPr29940

PHOSPHORYLATION

431

Y

PhosphoSitePlus

473820

LTP

N